分會

第四十分會：膠體與界面化學(xué)

摘要

玉米蛋白/短肽超分子水下黏合劑的構(gòu)建與生物應(yīng)用 聶俊蓮，文光，李文* 吉林大學(xué)超分子結(jié)構(gòu)與材料國家重點(diǎn)實(shí)驗(yàn)室，吉林省長春市前進(jìn)大街2699號，130012 *Email: wenli@jlu.edu.cn 蛋白質(zhì)和短肽的組合為創(chuàng)造新型的生物材料開辟了新思路。本研究以天然植物蛋白和短肽為構(gòu)筑單元通過簡單的共組裝方法開發(fā)了一種新型的生物黏合劑。利用十二烷基硫酸鈉對疏水玉米蛋白進(jìn)行分散形成穩(wěn)定的蛋白膠束，與陽離子短肽通過多重靜電/氫鍵等超分子相互作形成黏合劑。搭接剪切實(shí)驗(yàn)表明該黏合劑具有良好的水下粘接性能。體外和體內(nèi)實(shí)驗(yàn)表明該黏合劑具有良好的抗溶脹性、低細(xì)胞毒性、血液相容性和炎癥反應(yīng)。爆破壓實(shí)驗(yàn)表明該黏合劑可抵抗78 cmH2O以上的壓力，足以滿足硬膜缺損的密封要求。降解實(shí)驗(yàn)表明該黏合劑在體內(nèi)可以兩周內(nèi)解離和降解，與硬膜修復(fù)的時(shí)間吻合。綜合以上優(yōu)勢將該黏合劑成功應(yīng)用于硬膜缺損的密封和修復(fù)。 關(guān)鍵詞：玉米蛋白；短肽；共組裝；超分子聚合物；生物黏合劑 參考文獻(xiàn) [1] Nie, J.; Sun, Y.; Chen, X.; Wen, G.; Liu, X.; Cheng, M.; Zhao, J.; Li, W. Adv. Healthc. Mater. 2023, adhm.202203301R1. [2] Li, X.; Zheng, T.; Liu, X.; Du, Z.; Xie, X.; Li, B.; Wu, L.; Li, W. Langmuir 2019, 35(14): 4995. Zein/peptide supramolecular underwater adhesive for biological application Junlian Nie, Guang Wen, Wen Li* Department of Chemistry, University of Jilin, Qianjin Avenue 2699, Changchun, 130012 The fusion of protein science and peptide science opens up new frontiers in creating innovative biomaterials. Here, a new kind of biological adhesive based on a natural occurring plant protein and short peptides via a simple co-assembly route were explored. The hydrophobic zein was supercharged by sodium dodecyl sulfate to form stable protein colloid, which intended to interact with cationic short peptide via multivalent ionic and hydrogen bonds. Lap shear experiments show that the adhesive has strong underwater adhesion property. In vitro and in vivo assays demonstrate that the zein/peptide adhesive show excellent anti-swelling property, low cell cytotoxicity, hemocompatibility and inflammation response. Bursting pressure test suggests that the adhesive can resist over 78 cmH2O of bursting pressure, which was enough to meet the sealing requirements of dural defects. Degradation experiments show that the adhesive could in vivo dissociated and degraded within two weeks, which can well match with the time-window of the dural repairing. All these comprehensive features enable the zein/peptide adhesive to be explored as surgical adhesive for successful sealing and repairing the dural defect.

關(guān)鍵詞

玉米蛋白；短肽；共組裝；超分子聚合物；生物黏合劑

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