分會(huì)

第四十五分會(huì)：納米生物分析與納米藥物化學(xué)

摘要

The unique tumor microenvironment (TME) characteristics such as immunosuppression impeded traditional cancer treatments. In contrast, developing cascade catalytic nanoplatforms by fully making use of substances in TME for cancer therapy might deserve full credit. Herein, we developed a cascade catalytic nanoplatform based on glucose oxidase (GOD) modified mesoporous iron oxide nanoparticles (IONP) loaded with Artemisinin (ART), which was designed as IONP-GOD@ART. GOD could catalyze the oxidization of glucose into gluconic acid and H2O2, which not only realized tumor starvation therapy, but also provided H2O2 for IONP mediated Fenton reaction. Simultaneously, mesoporous IONP would release Fe2+ and Fe3+ ions in acidic TME. On one hand, iron ions underwent Fenton reaction to generate hydroxyl radicals for chemodynamic therapy. On the other hand, the endoperoxide bridge in ART was broken in presence of Fe2+ and further generated reactive oxygen species (ROS) to achieve therapeutic purpose. In this sense, IONP-GOD@ART manipulated TME characteristics and led to “butterfly effect”, which brought out a large amount of ROS for eliciting immunogenic cell death, inducing M1-TAMs polarization, and further reprogramming immunosuppressive TME for enhanced immunotherapy. By this delicate design, the cascade catalytic nanoplatform of IONP-GOD@ART would realize potent cancer immunotherapy for tumor regression and metastasis prevention.

關(guān)鍵詞

cascade catalysis;immunotherapy;glucose oxidase;Fenton reaction

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