雷曉光

男， 北京大學(xué)化學(xué)與分子工程學(xué)院， 教授/研究員/教授級高工或同等級別

學(xué)習(xí)/工作經(jīng)歷

1997.09-2001.06，北京大學(xué) 化學(xué)與分子工程學(xué)院，本科生
2001.08-2006.10，美國波士頓大學(xué) 化學(xué)系，博士
2006.11-2008.09，美國哥倫比亞大學(xué) 化學(xué)系，博士后
2008.10-2014.03，北京生命科學(xué)研究所，研究員
2014.04-現(xiàn)在，北京大學(xué) 化學(xué)與分子工程學(xué)院，教授
2014.04-現(xiàn)在，北大-清華生命科學(xué)聯(lián)合研究中心，資深研究員

研究領(lǐng)域和興趣

有機(jī)合成化學(xué)與化學(xué)生物學(xué)

主要業(yè)績

申請人雷曉光教授在有機(jī)合成化學(xué)領(lǐng)域具有特長，同時(shí)也能夠開展高水平的化學(xué)生物學(xué)與創(chuàng)新藥物研究工作，其代表性學(xué)術(shù)成果充分體現(xiàn)了他在化學(xué)與生物醫(yī)學(xué)交叉研究領(lǐng)域的優(yōu)勢和創(chuàng)新精神。獨(dú)立工作以來，他在活性天然產(chǎn)物全合成以及細(xì)胞死亡的化學(xué)生物學(xué)研究領(lǐng)域取得了一系列標(biāo)志性成果，達(dá)到了國際領(lǐng)先水平，得到了國內(nèi)外合成化學(xué)家以及化學(xué)生物學(xué)家的普遍認(rèn)同。他已經(jīng)完成了近80個(gè)復(fù)雜天然產(chǎn)物分子的高效全合成，其中超過50個(gè)全合成是在國際上報(bào)道的首次全合成。他還進(jìn)一步系統(tǒng)地利用多個(gè)天然產(chǎn)物分子探針開展深入的化學(xué)生物學(xué)研究，揭示出一系列調(diào)控程序性細(xì)胞死亡的新的藥物靶點(diǎn)和生物作用機(jī)制，為創(chuàng)新型抗炎、抗腫瘤藥物、以及抗生素的開發(fā)提供了有效的天然產(chǎn)物藥物先導(dǎo)。他目前作為通訊作者已經(jīng)在Cell，Nature Chemistry, Nature Chemical Biology，Chem, PNAS, JACS等高水平學(xué)術(shù)期刊上發(fā)表論文90余篇，獲得與創(chuàng)新藥物相關(guān)的中國、美國、歐盟等發(fā)明專利授權(quán)10余項(xiàng)，包括有兩個(gè)創(chuàng)新型候選藥物分子實(shí)現(xiàn)了科研轉(zhuǎn)化。他已經(jīng)獲得了18項(xiàng)國內(nèi)外重要學(xué)術(shù)榮譽(yù)，包括：國家杰青，青年拔尖人才，中青年科技創(chuàng)新領(lǐng)軍人才等。他曾榮獲2017 Tetrahedron Young Investigator Award（四面體青年科學(xué)家獎(jiǎng)）。這是中國科學(xué)家首次在生物有機(jī)化學(xué)與藥物化學(xué)領(lǐng)域獲得該重要國際學(xué)術(shù)獎(jiǎng)項(xiàng)。

代表成果

代表性論文：

1. Pei Mia, Haijun Wang, Wei Wan, Zhengdong Wan, Han Ke, Hangyuan Chen, Jinjing Ni, Jingnan Liang, Yu-Feng Yao, Jizong Wang, Jian-Min Zhou*, and Xiaoguang Lei* “A lineage non-specific phytoalexin disarms bacterial type III injectisome assembly” Science 2024, accepted
2. Jun Yang, Tianjun Zhao, Junping Fan, Huaibin Zou, Guangyi Lan, Fusheng Guo Yaocheng Shi, Han Ke, Huasheng Yu, Zongwei Yue, Xin Wang, Yingjie Bai, Shui Li, Yingjun Liu, Xiaoming Wang, Yu Chen*, Yulong Li*, Xiaoguang Lei* “Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch” Cell 2024, 187, 1-19. (Highlighted by C&E News)
3. Bin Jiang, Lei Gao, Haijun Wang, Yaping Sun, Xiaolin Zhang, Han Ke, Shengchao Liu, Pengchen Ma, Qinggang Liao, Yue Wang, Huan Wang, Yugeng Liu, Ran Du, Torben Rogge, Wei Li, Yi Shang, K. N. Houk, Xingyao Xiong, Daoxin Xie, Sanwen Huang, Xiaoguang Lei*, Jianbin Yan* “Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III” Science 2024, 383, 622-629. (Highlighted by C&E News)
4. Haoran Dong, Nianxin Guo, Dachao Hu, Benke Hong, Daohong Liao, Hong Jie Zhu, Zhang Yuan Yan, Hui Ming Ge, Xiaoguang Lei* “Chemoenzymatic Total Synthesis of Alchivemycin A” Nature Synthesis, 2024, DOI : 10.1038/s44160-024-00577-7 (Highlighted by C&E News)
5. Lei Gao, Qi Ding, Xiaoguang Lei* “Hunting for the intermolecular Diels-Alderase” Acc. Chem. Res. 2024, 57, 2166–2183 (Cover article)
6. Fusheng Guo, Fan Xiao, Hao Song, Xiaoyong Li, Yaxin Xiao, Yong Qin*, Xiaoguang Lei* “An optimized marinopyrrole A derivative targets GlmS to inhibit MRSA” ACS Cent. Sci. 2024, doi.org/10.1021/acscentsci.4c01167
7. Jin Wang, Jianxiong Zhao, Zhenyang Yu, Siyuan Wang, Fusheng Guo, Jun Yang, Lei Gao, Xiaoguang Lei* “Concise and Modular Chemoenzymatic Total Synthesis of Bisbenzylisoquinoline Alkaloids” Angew. Chem. Int. Ed. 2024, DOI: 10.1002/202414340
8. Haowen Zhang, Shuhan Xie, Jun Yang, Ning Ye Feng Gao, Fabrice Gallous, Lei Gao,* and Xiaoguang Lei* “Chemoenzymatic Synthesis of 2-Aryl Thiazolines from 4-Hydroxybenzaldehydes Using Vanillyl Alcohol Oxidases” Angew. Chem. Int. Ed. 2024, 63, e202405833
9. Kai Wang, Zhiwei Zhang, Jing Hang, Jia Liu, Fusheng Guo, Yong Ding, Meng Li, Qixing Nie, Jun Lin, Yingying Zhuo, Lulu Sun, Qihang Zhong, Chuan Ye, Chuyu Yun, Yi Zhang, Jue Wang, Rui Bao, Yanli Pang, Guang Wang*, Frank J. Gonzalez*, Xiaoguang Lei*, Jie Qiao*, Changtao Jiang* “Microbial-host-isozyme analyses reveal microbial DPP4 inhibition as a potential antidiabetic target” Science 2023, 381, eadd5787
10. Sanshan Wang, Kaiqi Chen, Fusheng Guo, Wenneng Zhu, Chendi Liu, Haoran Dong, Jin-Quan Yu*, Xiaoguang Lei* “C–H Glycosylation of Native Carboxylic Acids: Discovery of Antidiabetic SGLT-2 Inhibitors” ACS Cent. Sci. 2023, 9, 1129–1139
11. Junping Fan, Linghan Hu, Zongwei Yue, Daohong Liao, Fusheng Guo, Han Ke, Daohua Jiang*, Yong Yang*, Xiaoguang Lei* “Structural basis of TRPV3 inhibition by an antagonist” Nature Chemical Biology 2023, 19, 81-90
12. Haoran Dong, Dachao Hu, Benke Hong, Jin Wang, Xiaoguang Lei* “Total Syntheses of Diverse Tetramic Acid-Bearing cis-Decalin Natural Products” Angew. Chem. Int. Ed. 2023, 62, e202301872
13. Jianyong Du, Lixia Zheng, Peng Gao, Hang Yang, Wan-Jie Yang, Fusheng Guo, Ruqi Liang, Mengying Feng, Zihao Wang, Zongwang Zhang, Linlu Bai, Ye Bu, Shijia Xing, Wen Zheng, Xuelian Wang, Li Quan, Xinli Hu, Haosen Wu, Zhixing Chen, Liangyi Chen, Ke Wei, Zhe Zhang, Xiaojun Zhu, Xiaolin Zhang, Qiang Tu, Shi-Min Zhao*, Xiaoguang Lei*, Jing-Wei Xiong* “A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration” Cell Stem Cell 2022, 29, 545-558
14. Jun Zhang, Daohong Liao, Rongchang Chen, Fangfang Zhu, Yaqing Ma, Lei Gao, Ge Qu, Chengsen Cui, Zhoutong Sun*, Xiaoguang Lei*, Shu-Shan Gao* “Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering” Angew. Chem. Int. Ed. 2022, 61, e202201908
15. Lei Gao, Yike Zou, Xiaojing Liu, Jun Yang, Xiaoxia Du, Jin Wang, Xinshui Yu, Junping Fan, Mingxuan Jiang, Yuli Li, K. N. Houk*, Xiaoguang Lei* “Enzymatic control of endo and exo stereoselective Diels-Alder reactions with broad substrate scope” Nature Catalysis 2021, 4, 1059-1069
16. Lei Gao, Cong Su, Xiaoxia Du, Ruishan Wang, Shuming Chen, Yu Zhou, Chengwei Liu, Xiaojing Liu, Runze Tian, Liyun Zhang, Kebo Xie, She Chen, Qianqian Guo, Lanping Guo, Yoshio Hano, Manabu Shimazaki, Atsushi Minami, Hideaki Oikawa, Niu Huang, K. N. Houk, Luqi Huang*, Jungui Dai*, Xiaoguang Lei* "FAD-dependent Enzyme-Catalysed Intermolecular [4+2] Cycloaddition in Natural Product Biosynthesis" Nature Chemistry, 2020, 12, 620-628. (Highlighted by Chemistry World)
17. Wang W, Yang J, Zhang J, Liu YX, Tian C, Qu B, Gao C, Xin P, Cheng S, Zhang W, Miao P, Li L, Zhang X, Chu J, Zuo J, Li J, Bai Y, Lei X,* Zhou JM* “An Arabidopsis Secondary Metabolite Directly Targets Expression of the Bacterial Type III Secretion System to Inhibit Bacterial Virulence” Cell Host & Microbe 2020, 27, 601–613
18. Wu, F.; Zhang, J.; Song, F.; Wang, S.; Guo, H.; Wei, .; Dai, H.; Chen, X.; Xia, X.; Liu, X.; Zhang, L.; Yu, J.-Q.; Lei, X.* “Chrysomycin A Derivatives for the Treatment of Multidrug Resistant Tuberculosis” ACS Cent. Sci. 2020, 6, 928-938
19. Bai, Y.; Lam, H.C.; Lei, X.* “Dissecting Programmed Cell Death with Small Molecules” Acc. Chem. Res. 2020, 53, 1034-1045
20. Weilong Liu, Benke Hong, Jin Wang, Xiaoguang Lei* “New Strategies in the Efficient Total Syntheses of Polycyclic Natural Products” Acc. Chem. Res. 2020, 53, 2569–2586
21. Wang J, Hong B, Hu D, Kadonaga Y, Tang R, Lei X.* “Protecting-Group-Free Syntheses of ent-Kaurane Diterpenoids: [3+2+1] Cycloaddition/Cycloalkenylation Approach.” J. Am. Chem. Soc. 2020, 142, 2238-2243
22. Hong, B.; Luo, T.; Lei, X.* “Late-Stage Diversification of Natural Products” ACS Cent. Sci. 2020, 6, 622-635
23. Zongwei Yue, Hiu C. Lam, Kaiqi Chen, Ittipon Siridechakorn, Yaxi Liu, Khanitha Pudhom, Xiaoguang Lei* “Biomimetic synthesis of rhytidenone A and elucidation of mode of action of the cytotoxic rhytidenone F” Angew. Chem. Int. Ed. 2020, 59, 4115-4120
24. Sourav Banerjee, Tiantian Wei, Jue Wang, Jenna J. Lee, Haydee L. Gutierrez, Owen Chapman, Sandra E. Wiley, Joshua E. Mayfield, Vasudha Tandon, Edwin F. Juarez, Lukas Chavez, Ruqi Liang, Robert L. Sah, Caitlin Costello, Jill P. Mesirov, Laureano de la Vega, Kimberly L. Cooper, Jack E. Dixon*, Junyu Xiao*, and Xiaoguang Lei* “Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression” Proc. Natl Acad. Sci. USA 2019, 116, 24881-24891
25. Benke Hong, Weilong Liu, Jin Wang, Jinbao Wu, Yuichiro Kadonaga, Pei-Jun Cai, Hong-Xiang Lou, Zhixiang Yu, Houhua Li*, Xiaoguang Lei* “Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids” Chem 2019, 6,1671-1681 (Featured Article)
26. Jinbao Wu, Yuichiro Kadonaga, Benke Hong, Jin Wang, Xiaoguang Lei* “Enantioselective Total Synthesis of (+)-Jungermatrobrunin A” Angew. Chem. Int. Ed. 2019, 58, 10879-10883
27. Zhuang, S.; Li, Q.; Cai, L.; Wang, C.*; Lei, X.* “Chemoproteomic Profiling of Bile Acid Interacting Proteins” ACS Cent. Sci. 2017, 3, 501-509
28. Liao, D.; Yang, S.; Wang, J.; Zhang, J. Hong, B.; Wu, F.; Lei, X.* “Total Synthesis and Structural Reassignment of Aspergillomarasmine A” Angew. Chem. Int. Ed. 2016, 55, 4291-4295
29. Liu, W.; Li, H.; Cai, P.; Wang, Z.; Yu, Z-X.; Lei, X.* “Scalable Total Synthesis of Jungermannenones B and C” Angew. Chem. Int. Ed. 2016, 55, 3112-3116. (Highlighted by Synfacts 2016, 12, 0332)
30. Hong, B.; Li, C.; Wang, Z.; Chen, J.; Li, H.*; Lei, X.* “Enantioselective Total Synthesis of (-)-Incarviatone A” J. Am. Chem. Soc. 2015, 137, 11946-11949. (News story describing this work was highlighted by Chem. & Eng. News 2015, 93, 35 and Synfacts 2015, 11, 1231)
31. Hong, B.; Li, H.; Wu, J.; Zhang, J. Lei, X.* “Total Syntheses of (-)-Huperzine Q and (+)-Lycopladines B and C” Angew. Chem. Int. Ed. 2015, 54, 1011-1015. (Highlighted by Synfacts 2015, 11, 0112)
32. Li, C.; Dong, T.; Li, Q.; Lei, X.* “Probing the Anti-cancer Mechanism of (-)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation” Angew. Chem. Int. Ed. 2014, 53, 12111-12115
33. Han, J.; Li, X.; Guan, Y.; Zhao, W.; Wullf, W. D.*; Lei, X.* “Enantioselective Biomimetic Total Syntheses of Kuwanons I and J and Brosimones A and B” Angew. Chem. Int. Ed. 2014, 53, 9257-9261
34. Li, Q.; Dong, T.; Liu, X.; Lei, X.* “A Bioorthogonal Ligation Enabled by Click Cycloaddition of o-Quinolinone Quinone Methide and Vinyl Thioether” J. Am. Chem. Soc. 2013, 135, 4996-4999. (News story describing this work was highlighted in Chem. & Eng. News 2013, 14, 37)
35. Wang, G.*; Wang, X.; Yu, H.; Wei, S.; Williams, N.; Holmes, D. L.; Halfmann, R.; Naidoo, J.; Wang, L.; Li, L.; Chen, S.; Harran, P.; Lei, X.*; Wang, X.* “Small Molecule Activation of the TRAIL Receptor DR5 in Human Cancer Cells” Nature Chem. Biol. 2013, 9, 84-89. (News stories describing this work were highlighted in Chem. & Eng. News 2013, 2, 37; Nature Asia 2012, December 24)
36. Li, C.; Dian, L.; Zhang, W.; Lei, X.* “Biomimetic Syntheses of (-)-Gochnatiolides A-C and (-)-Ainsliadimer B” J. Am. Chem. Soc. 2012, 134, 12414-12417
37. Li, H.; Wang, X.; Lei, X.* “Total Syntheses of Lycopodium Alkaloids (+)-Fawcettimine, (+)-Fawcettidine and (-)-8-Deoxyserratinine” Angew. Chem. Int. Ed. 2012, 51, 491-495; Angew. Chem. 2012, 124, 506-510
38. Sun, L.; Wang, H.; Wang, Z.; He, S.; Chen, S.; Liao, D.; Wang, L.; Yan, J.; Liu, W.; Lei, X.*; Wang, X.* “Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase” Cell 2012, 148, 213-227. (News stories describing this work were highlighted in Chem. & Eng. News 2012, 5, 40; Nature China 2012, February 1; Asian Scientist 2012, January31; and Nature Reviews Molecular Cell Biology, 2012, Feb. 8)



專利授權(quán)：
序號 申請(授權(quán))號 申請(授權(quán))日 專利權(quán)人 發(fā)明人 發(fā)明名稱
1 ZL201910455532.7 20210709 北京大學(xué) 雷曉光，吳凡，岳宗偉，郭富生 一種化合物及其合成方法與應(yīng)用
2 ZL2018106510186 20210105 北京大學(xué) 雷曉光，張健，楊榮文，趙天湖 一種綠膿桿菌代謝物及其衍生物、合成方法與應(yīng)用
3 ZL201911066291.3 20210810 北京大學(xué) 雷曉光，唐毓良，董夢秋，王建華 一種蛋白質(zhì)化學(xué)交聯(lián)劑及其制備方法與應(yīng)用
4 ZL201911074314.5 2021/4/13 北京大學(xué) 雷曉光，肖凡，唐毓良 蛋白質(zhì)定量標(biāo)記試劑及其制備方法與應(yīng)用
5 ZL201911136243.7 20211008 北京大學(xué) 雷曉光，戴均貴，高磊，蘇聰 一種Diels-Alder反應(yīng)酶及其應(yīng)用
6 ZL201911135070.7 20211119 北京大學(xué) 雷曉光，郭倩倩，高磊
一種AMA合成酶及其在合成AMA或其衍生物中的應(yīng)用
7 ZL201911136241.8 20211119 北京大學(xué) 雷曉光，高磊，劉小晶
一種Diels-Alder反應(yīng)酶的應(yīng)用及其突變體的制備方法與應(yīng)用
8 ZL202010324004.0 20210709 北京大學(xué) 雷曉光;?趙天湖;?張健一種熒光素偶聯(lián)體及其合成方法與應(yīng)用
9 ZL2021112288768 20211021 北京大學(xué) 雷曉光；高磊 一種分子間exo 選擇性Diels-Alder 反應(yīng)酶及其應(yīng)用

著作：
雷曉光，《化學(xué)生物學(xué)》--第二章 生物體的化學(xué)起源，化學(xué)工業(yè)出版社，2022，北京
雷曉光，肖友利，郝小江《中國天然產(chǎn)物發(fā)現(xiàn)的十年攀登》--第六章 基于天然產(chǎn)物的化學(xué)生物學(xué)研究，科學(xué)出版社，2022，北京
雷曉光，張力云，白英杰《Progress in the Chemistry of Organic Natural Products》-第四章 Human Endogenous Natural Products，Springer，2021，Switzerland

*以上信息由高級會員個(gè)人更新和維護(hù)。