劉震

男， 南京大學(xué)， 教授/研究員/教授級(jí)高工或同等級(jí)別

學(xué)習(xí)/工作經(jīng)歷

1988.09-1992.06，貴州大學(xué)化學(xué)系，本科生；
1992.09-1995.06，南京大學(xué)化學(xué)系，碩士生；
1995.09-1998.06，中國(guó)科學(xué)院大連化學(xué)物理研究所，博士生；
1998.07-2000.01，中國(guó)科學(xué)院大連化學(xué)物理研究所，助理研究員；
2001.02-2002.01，日本兵庫(kù)大學(xué)理學(xué)部，日本學(xué)術(shù)振興會(huì)（JSPS）特別研究員；
2002.02-2007.08，中國(guó)科學(xué)院大連化學(xué)物理研究所，訪問學(xué)者；
2002.08-2005.11，加拿大滑鐵盧大學(xué)化學(xué)系，博士后；
2005.11-今，南京大學(xué)化學(xué)化工學(xué)院，教授

研究領(lǐng)域和興趣

生物分離、生物質(zhì)譜、仿生分子識(shí)別、疾病診斷、單細(xì)胞分析、納米醫(yī)學(xué)

主要業(yè)績(jī)

2005年獲聘南京大學(xué)教授，2006年起任博士生導(dǎo)師，2008年入選教育部“新世紀(jì)優(yōu)秀人才”， 2011年-2014年任加拿大滑鐵盧大學(xué)工程學(xué)院兼職教授，2014年獲國(guó)家杰出青年科學(xué)基金，2016年入選江蘇省“333高層次人才”（第二層次）。兼任國(guó)際分子印跡學(xué)會(huì)理事會(huì)理事、中國(guó)質(zhì)譜學(xué)會(huì)常務(wù)理事、中國(guó)化學(xué)會(huì)質(zhì)譜專業(yè)委員會(huì)委員、中國(guó)生物化學(xué)與分子生物學(xué)會(huì)蛋白質(zhì)組學(xué)專業(yè)委員會(huì)委員、《Analytica Methods》副主編、《Analytica Chimica Acta》、《Electrophoresis》、《Separation Science Plus》、《科學(xué)通報(bào)》、《分析化學(xué)》、《質(zhì)譜學(xué)報(bào)》和《色譜》等雜志編委。主持國(guó)家重大科研儀器項(xiàng)目和基金委重點(diǎn)項(xiàng)目等國(guó)家級(jí)科研項(xiàng)目10余項(xiàng)，已在Chemical Society Review，Accounts of Chemical Research，Angewandte Chemie International Edition，Nature Protocols，Chemical Science等期刊上發(fā)表論文140余篇，目前h因子46（谷歌學(xué)術(shù)），主編及合著著作2部，出版專章7章，獲授權(quán)專利12項(xiàng)。2011年和2017年先后獲中國(guó)分析測(cè)試協(xié)會(huì)科學(xué)技術(shù)獎(jiǎng)一等獎(jiǎng)共2次，2016年獲Phenomenex & Analytical Scientist聯(lián)合頒發(fā)的科學(xué)人文獎(jiǎng)銀獎(jiǎng)。2020年榮獲美國(guó)化學(xué)會(huì)（ACS）測(cè)量科學(xué)進(jìn)展講座獎(jiǎng)（Advances in Measurement Science Lectureship Award）。主要從事分子識(shí)別、親和分離、疾病診斷、單細(xì)胞分析和癌癥納米治療等研究，主要代表性成果有：1、系統(tǒng)深入地研究了硼親和色譜及相關(guān)親和材料及技術(shù)；2、建立了多個(gè)便捷高效的分子印跡方法，推動(dòng)了分子印跡聚合物在生物醫(yī)學(xué)等重要領(lǐng)域中的應(yīng)用；3、建立了等離激元免疫夾心法，成功應(yīng)用于疾病診斷和單細(xì)胞分析等領(lǐng)域；4、提出了基于分子印跡聚合物的抗癌納米藥物 。

代表成果

I. 論文：
1. Menghuan Zhao, Peixin Guan, Shuxin Xu, Haifeng Lu, Zhen Liu*. Molecularly imprinted nanomedicine for anti-angiogenic cancer therapy via blocking VEGF signaling. Nano Letters, 2023, 23, 18, 8674–8682.
2. Jingran Chen, Shuxin Xu, Qing Ye, Hang Chi, Ying Li, Mei Wu, Baochao Fan, Zhanchen Guo, Cheng-Feng Qin, Bin Li, Zhen Liu*. A topology-matching spike protein-capping tetrahedral DNA nanocrown for SARS-CoV-2 neutralization. CCS Chemistry, 2023, 5, 1372–1385.
3. Zikuan Gu, Zhanchen Guo, Song Gao, Lingrui Huang, Zhen Liu*. Hierarchically structured molecularly imprinted nanotransducers for truncated HER2-targeted photodynamic therapy of therapeutic antibody-resistant breast cancer. ACS Nano, 2023, 17, 10152–10163.
4. Wei Li, Shuxin Xu, Ying Li, Jingran Chen, Yanyan Ma, Zhen Liu*. High mannose-specific aptamers for broad-spectrum virus inhibition and cancer targeting. CCS Chemistry, 2023, 5, 497-509.
5. Juntao Zhou, Xianhui Cheng, Zhanchen Guo, Muhammad Mujahid Ali, Guiyuan Zhang, W. Andy Tao, Lianghai Hu*, Zhen Liu*. Epitope imprinting of phospholipids by oriented assembly at oil/water interface for the selective recognition of plasma membranes. Angewandte Chemie International Edition, 2023, 62, e202213938 (Hot paper).
6. Peixin Guan, Zhanchen Guo, Shuxin Xu, Haifeng Lu, Lisheng Wang, Zikuan Gu, Zhen Liu*. Molecularly imprinted nanobeacons redirect innate immune killing towards triple negative breast cancer. Angewandte Chemie International Edition, 2023, 62, e202301202 (Hot paper).
7. Pengfei Li, Shuxin Xu, Yanjie Han, Hui He, Zhen Liu*. Machine learning-empowered cis-diol metabolic fingerprinting enables precise diagnosis of primary liver cancer, Chemical Science, 2023, 14, 2553 – 2561.
8. Hui He, Lingli Zhou, Zhanchen Guo, Pengfei Li, Song Gao, Zhen Liu*. Nanogap-enhanced Raman scattering for ultrasensitive protein fingerprinting and quantitation. Nano Letters, 2022, 22, 23, 9664–9671.
9. Ying Li, Shuxin Xu, Qing Ye, Hang Chi, Zhanchen Guo, Jingran Chen, Mei Wu, Baochao Fan, Bin Li, Cheng-Feng Qin*, Zhen Liu*. Rational development of hypervalent glycan shield-binding nanoparticles with broad-spectrum inhibition against fatal viruses including SARS-CoV-2 variants. Advanced Science, 2022, 10, 202202689.
10. Shuxin Xu, Menghuan Zhao, Zikuan Gu, Haifeng Lu, Zhen Liu*. Photothermal therapy of neuroblastoma via polysialic acid-targeting nanomissiles. Small, 2022, 18, 2201671.
11. Zikuan Gu, Shuxin Xu, Zhanchen Guo, Zhen Liu*. Rational development of molecularly imprinted nanoparticles for blocking PD-1/PD-L1 axis. Chemical Science, 2022, 13, 10897-10903.
12. Jilei Pang, Pengfei Li, Hui He, Shuxin Xu, Zhen Liu*. Molecularly imprinted polymers outperform lectin counterparts and enable more precise cancer diagnosis. Chemical Science, 2022,13, 4589-4597.
13. Pengfei Li, Jilei Pang, Shuxin Xu, Hui He, Yanyan Ma, Zhen Liu*. A glycoform-resolved dual-modal ratiometric immunoassay improves the diagnostic precision for hepatocellular carcinoma. Angewandte Chemie International Edition, 2022, 61, e202113528 (Hot paper).
14. Rongrong Xing, Zhanchen Guo, Haifeng Lu, Qi Zhang, Zhen Liu*. Molecular imprinting and cladding produces antibody mimics with significantly improved affinity and specificity. Science Bulletin, 2022, 67, 278-287.
15. Zhanchen Guo, Rongrong Xing, Menghuan Zhao, Ying Li, Haifeng Lu, Zhen Liu*. Controllable engineering and functionalizing of nanoparticles for targeting specific proteins towards biomedical applications. Advanced Science, 2021, 8, 2101713 (Highly cited paper).
16. Haifeng Lu, Shuxin Xu, Zhanchen Guo, Menghuan Zhao, Zhen Liu*. Redox-responsive molecularly imprinted nanoparticles for targeted intracellular delivery of protein toward cancer therapy. ACS Nano, 2021, 15, 18214?18225.
17. Jia Liu, Hui He, Dan Xie, Yanrong Wen, Zhen Liu*. Probing low-copy-number proteins in single living cells using single-cell plasmonic immunosandwich assays. Nature Protocols, 2021, 16, 3522–3546.
18. Shuxin Xu, Lisheng Wang, Zhen Liu*. Molecularly imprinted polymer nanoparticles: An emerging versatile platform for cancer therapy. Angewandte Chemie International Edition, 2021, 60, 3858-3869.
19. Zikuan Gu, Yueru Dong, Shuxin Xu, Lisheng Wang, Zhen Liu*. Molecularly imprinted polymer-based smart prodrug delivery system for specific targeting, prolonged retention and tumor microenvironment-triggered release. Angewandte Chemie International Edition, 2021, 60, 2663–2667.
20. Yueru Dong, Wei Li, Zikuan Gu, Rongrong Xing, Yanyan Ma, Qi Zhang, Zhen Liu*. Inhibition of HER2-positive breast cancer growth by blocking the HER2 signaling pathway with HER2 glycan-imprinted nanoparticles. Angewandte Chemie International Edition, 2019, 58, 10621-10625 (Hot paper, Featured in [Angewandte Chemie], [EurekAlert!], [SicenceDaily], [PhysOrg.com], [Cancernetwork], [Nanowerk], [Chemistryviews.org], [News-medical.net]…).
21. Rongrong Xing, Yanyan Ma, Yijia Wang, Yanrong Wen, Zhen Liu*. Specific recognition towards proteins and peptides via controllable oriented surface imprinting of boronate affinity-anchored epitope. Chemical Science, 2019, 10, 1831-1835.
22. Jia Liu, Yanrong Wen, Hui He, Hong-Yuan Chen, Zhen Liu*. Probing cytoplasmic and nuclear microRNAs in single living cells via plasmonic affinity sandwich assay. Chemical Science, 2018, 9, 7241 - 7246.
23. Zhen Liu*, Hui He. Synthesis and Applications of Boronate Affinity Materials: from Class-selectivity to Biomimetic Specificity. Accounts of Chemical Research, 2017, 50, 2185–2193 (Highly cited paper).
24. Rongrong Xing, Shuangshou Wang, Zijun Bie, Hui He, Zhen Liu*. Preparation of molecularly imprinted polymers specific to glycoproteins, glycans and monosaccharides via boronate affinity controllable oriented surface imprinting. Nature Protocols, 2017, 12, 964–987 (Highly cited paper).
25. Jia Liu, Danyang Yin, Shuangshou Wang, Hong-Yuan Chen, Zhen Liu*. Probing Low-Copy Number Proteins in a Single Living Cell. Angewandte Chemie International Edition, 2016, 55, 13215–13218.
26. Daojin Li, Yang Chen, Zhen Liu*. Boronate affinity materials for separation and molecular recognition: structure, properties and applications. Chemical Society Reviews, 2015, 44, 8097-8123 (Highly cited paper).
27. Zijun Bie, Yang Chen, Jin Ye, Shuangshou Wang, Zhen Liu*. Boronate-Affinity Glycan-Oriented Surface Imprinting: A New Strategy to Mimic Lectins for the Recognition of an Intact Glycoprotein and Its Characteristic Fragments. Angewandte Chemie International Edition, 2015, 54, 10211-10215 (VIP, Highly cited paper).
28. Xianghua Pan, Yang Chen, Peixuan Zhao, Daojin Li, Zhen Liu*. Highly Efficient Solid-Phase Labeling of Saccharides within Boronic Acid Functionalized Mesoporous Silica Nanoparticles. Angewandte Chemie International Edition, 2015, 54, 6173–6176.
29. Jin Ye, Yang Chen, Zhen Liu*. Boronate Affinity Sandwich Assay: an Appealing Alternative of Immunoassay for the Determination of Glycoproteins. Angewandte Chemie International Edition, 2014, 53, 10386-10389.
30. Qianjin Li, Xueying Tu, Jin Ye, Zijun Bie, Xiaodong Bi, Zhen Liu*. Nanoconfining affinity materials for pH-mediated protein capture-release. Chemical Science, 2014, 5, 4065-4069.
31. Shuangshou Wang, Jin Ye, Zijun Bie, Zhen Liu*. Affinity-tunable specific recognition of glycoproteins via boronate affinity-based controllable oriented surface imprinting. Chemical Science, 2014, 5, 1135-1140.
32. Heye Wang, Zijun Bie, Chenchen Lü, Zhen Liu*. Magnetic nanoparticles with dendrimer-assisted boronate avidity for the selective enrichment of trace glycoproteins. Chemical Science, 2013, 4, 4298 - 4303.
33. Li Li, Yue Lu, Zijun Bie, Hong-Yuan Chen, Zhen Liu*. Photolithographic Boronate Affinity Molecular Imprinting: a General and Facile Approach for Glycoprotein Imprinting. Angewandte Chemie International Edition, 2013, 52, 7451-7454.
34. Yunchun Liu, Yue Lu, Zhen Liu*. Restricted access boronate affinity porous monolith as a protein A mimetic for the specific capture of immunoglobulin G. Chemical Science, 2012, 3, 1467-1471.
35. Lianbing Ren, Zhen Liu*, Yunchun Liu, Peng Dou, Hong-Yuan Chen. Ring-opening polymerization with synergistic co-monomers: access to a boronate-functionalized polymeric monolith for the specific capture of cis-diol-containing biomolecules under neutral conditions. Angewandte Chemie International Edition, 2009, 48, 6704-6707.

II. 專利
1、 劉震、李迎、許舒欣、郭展辰、陳靜然。一種具有廣譜抗病毒效果的納米人工抗體及其制備方法。申請(qǐng)?zhí)枺?02210168578.2。申請(qǐng)日期：2022-02-23。授權(quán)號(hào)：CN114533754A。授權(quán)日期：2023-10-20。
2、 劉震、郭展辰、邢榮榮?；诜聪辔⑷橐旱姆肿佑≯E及包覆聚合物、制備方法及用途。申請(qǐng)?zhí)枺?02110482677.3。申請(qǐng)日期：2021-07-26。授權(quán)號(hào)：CN115254048A。授權(quán)日期：2023-06-13。
3、 劉震、邢榮榮、郭展辰、張齊。一種分子印跡及包覆聚合物、其制備方法及用途。申請(qǐng)?zhí)枺?02110481022.4。申請(qǐng)日期：2021-07-14. CN115254047A。授權(quán)號(hào)：CN115254047A。授權(quán)日期：2023-10-27。
4、 劉震、邢榮榮、王益佳。一種通用便捷的表位印跡方法及所得分子印跡聚合物的應(yīng)用。中國(guó)發(fā)明專利，申請(qǐng)?zhí)枺?01810538823.8。申請(qǐng)日期：2018-05-30。授權(quán)號(hào)：CN108722369B。授權(quán)日期：2020-12-25。
5、 劉震、劉佳、尹丹陽(yáng)、涂雪瑩、Pir Muhammad（皮耶 木合馬徳）。一種不同親和配基功能化的金基萃取材料及其在表面等離激元光學(xué)親和夾心分析中的應(yīng)用。中國(guó)發(fā)明專利，申請(qǐng)?zhí)枺?016107374705。申請(qǐng)日期：2016-08-24。授權(quán)號(hào)：CN106442459B。授權(quán)日期：2020-02-07。
6、 劉震，別子俊，陳陽(yáng)?；诜肿佑≯E技術(shù)的凝集素模擬物的合成方法與應(yīng)用。中國(guó)發(fā)明專利，申請(qǐng)?zhí)枺?01510182716.2。申請(qǐng)日期：2015-04-16。授權(quán)號(hào)：CN104820100A。授權(quán)日期：2017-05-03。
7、 劉震，李道金、張乾、劉百戰(zhàn)。一種樹枝狀硼酸功能化整體柱及其制備方法和應(yīng)用。中國(guó)發(fā)明專利，申請(qǐng)?zhí)枺?01410856918.6。申請(qǐng)日期：2014-12-29。授權(quán)公告號(hào)：CN 104549182 B；授權(quán)日期：2017-07-07。
8、 劉震，葉金。基于分子印跡技術(shù)和拉曼光譜的糖蛋白檢測(cè)方法及應(yīng)用。中國(guó)發(fā)明專利，申請(qǐng)?zhí)枺?01410255065.0。申請(qǐng)日期：2014-06-11。授權(quán)公告號(hào)：CN104122247B。授權(quán)日期：2017-01-25。
9、 劉震，王雙壽。一種熒光納米探針及其制備方法和應(yīng)用。中國(guó)發(fā)明專利，申請(qǐng)?zhí)枺?014100368865。申請(qǐng)日期：2014-01-26。授權(quán)日期：2016-03-12。CN103937486B。
10、 劉震，王雙壽，畢曉東。一種可控、通用的定向表面印跡方法以及所得分子印跡聚合物的應(yīng)用。中國(guó)發(fā)明專利，申請(qǐng)?zhí)枺?01310339600.6。申請(qǐng)日期：2013-08-06。授權(quán)日期：2016-08-10。授權(quán)公告號(hào)：CN103406109B。

III． 著作
1、 劉震 主編. 《現(xiàn)代分離科學(xué)》，北京：化學(xué)工業(yè)出版社，2017年8月. 標(biāo)準(zhǔn)書號(hào)：978-7-122-30157-4.
2、 鄒漢法，劉震，葉明亮，張玉奎. 《毛細(xì)管電色譜及其應(yīng)用》, 北京：科學(xué)出版社，2001年12月. 標(biāo)準(zhǔn)書號(hào)：7-03-009078-0/O.1323.

*以上信息由高級(jí)會(huì)員個(gè)人更新和維護(hù)。