羅穩(wěn)

男， 河南大學(xué)， 教授/研究員/教授級高工或同等級別

學(xué)習(xí)/工作經(jīng)歷

2001/09–2005/06，河南大學(xué)，化學(xué)化工學(xué)院，化學(xué)，學(xué)士
2005/09–2008/06，河南大學(xué)，化學(xué)化工學(xué)院，有機(jī)化學(xué)，碩士，導(dǎo)師：趙瑾，王超杰
2008/09–2011/06，中山大學(xué)，藥學(xué)院，藥物化學(xué)，博士，導(dǎo)師：古練權(quán)，黃志紓
2011/07–至今，河南大學(xué)，天然藥物創(chuàng)新與轉(zhuǎn)化重點實驗室，工作
2018/09–2019/09，美國南佛羅里達(dá)大學(xué)，訪問學(xué)者，合作導(dǎo)師：季海濤

研究領(lǐng)域和興趣

藥物化學(xué)，化學(xué)生物學(xué)

主要業(yè)績

工作以來獲得河南省優(yōu)秀博士后，河南省青年骨干教師，開封市科技創(chuàng)新人才。主持國家自然科學(xué)基金2項，主持中國博士后項目，河南省科技廳項目以及河南省教育廳基金各1項。2018-2019在美國南佛羅里達(dá)大學(xué)莫菲特癌癥研究中心做訪問學(xué)者。工作以來共發(fā)表SCI研究論文五十余篇，授權(quán)國家發(fā)明專利6件。中國化學(xué)會、河南省化學(xué)會和河南省藥學(xué)會會員，河南省活性多肽類藥物工程中心顧問，省科學(xué)基金評審庫專家，多個藥學(xué)期刊雜志審稿人。

代表成果

1. Hui Zhou, Jihang Zhai, Huiyuan Gong, Ru Fang, Yongmei Zhao, Wen Luo*. Novel pyrrolidine-alkylamino-substituted dicyanoisophorone derivatives as near-infrared fluorescence probe for imaging β-amyloid in vitro and in vivo. Anal. Chim. Acta, 2024, 1317, 342894. Doi: 10.1016/j.aca.2024.342894.
2. Hui Zhou, Yang Li, Ru Fang, Jinghua Li, Chen Hong*, Wen Luo*. A dicyanoisophorone-based long-wavelength fluorescent probe for detection of cysteine in vitro and in vivo. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2024, 304, 123403. Doi: 10.1016/j.saa.2023.123403.
3. Yongmei Zhao, Jianwu Lv, Hongli Yu, Kang Huang, Zhihan Du, Wen Luo*. Dictamnine derivatives as a novel family of dual inhibitors for cholinesterase and β-amyloid aggregation. J. Mol. Struct., 2023, 1293, 136222. Doi: 10.1016/j.molstruc.2023.136222.
4. Zhiyang Zhang, Jianwu Lv, Yu Wang, Hongli Yu, Baolin Guo, Jihang Zhai, Chaojie Wang, Yuan Zhao*, Fangfang Fan*, Wen Luo*. Static binding and dynamic transporting-based design of specific ring-chain-ring acetylcholinesterase inhibitor: From galantamine to natural product. Chem. Eur. J., 2023, 29(25):e202203363. Doi: 10.1002/chem.202203363.
5. Jinghua Li , Shuai Chen , Yancong Zhao , Huiyuan Gong, Tong Wang, Xiaoling Ge, Yuxia Wang*, Chenguang Zhu, Liang Chen, Fujun Dai, Songqiang Xie, Chaojie Wang, Wen Luo*. Design, synthesis, and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as a lysosome-targeted anti-metastatic agent. Frontiers in Oncology. 2021, 11, 733589. Doi: 10.3389/fonc.2021.733589.
6. Yantao Liu, Wen Luo,* Zhenjie Wang, Yuxin Zhao, Jingjing Zhao,* Xuejun Xu, Chaojie Wang, Pan Li*. Visible-light photoredox-catalyzed formal [5+1] cycloaddition of N-tosyl vinylaziridines with difluoroalkyl halides. Org. Lett. 2020, 22, 9658?9664. Doi: 10.1021/acs.orglett.0c03718.
7. Juan Cen, Huiyan Guo, Chen Hong, Jianwu Lv, Yacheng Yang, Ting Wang, Dong Fang, Wen Luo*, Chaojie Wang*, Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity. Eur. J. Med. Chem., 2018, 144, 128-136. Doi: 10.1016/j.ejmech.2017.12.005.
8. Qian Li, Zi-xin Zhu, Xin Zhang, Wen Luo*, Li-ping Chang, Shuai Chen, Yu-xia Wang*, Song-qiang Xie, Cong-cong Chang, Chao-jie Wang*, The lead optimization of the polyamine conjugate of flavonoid with a naphthalene motif: Synthesis and biological evaluation. Eur. J. Med. Chem., 2018, 146, 564-576. Doi: 10.1016/j.ejmech.2018.01.074.
9. 羅穩(wěn)，李景華，黃抗，龔慧媛，趙永梅，一種同分異構(gòu)體、其制備方法及應(yīng)用，2020年申請，2021批準(zhǔn)，ZL 202011491607.6。
10. 羅穩(wěn)，呂劍伍，趙永梅，呋喃并喹啉衍生物、其制備方法及應(yīng)用，2020年申請，2021年批準(zhǔn)，ZL 202110116836.8。

*以上信息由高級會員個人更新和維護(hù)。