李家柱

男， 煙臺大學(xué)化學(xué)化工學(xué)院， 教授/研究員/教授級高工或同等級別

學(xué)習(xí)/工作經(jīng)歷

2000/09–2004/07，煙臺大學(xué)，生物技術(shù)，理學(xué)學(xué)士
2004/09–2007/07，煙臺大學(xué)，藥物化學(xué)，醫(yī)學(xué)碩士
2007/09–2012/02，Inje University（韓國），納米工學(xué)，工學(xué)博士
2012/03–2013/02，Yonsei University（韓國），博士后
2013/03–至今，煙臺大學(xué)，化學(xué)化工學(xué)院，講師、副教授、教授，碩士研究生導(dǎo)師

研究領(lǐng)域和興趣

卟啉與葉綠素化學(xué)、BODIPY、近紅外光敏劑、光動力療法

主要業(yè)績

主要從事葉綠素和BODIPY類光動力抗癌光敏劑的設(shè)計、合成與開發(fā)。主持并完成省部級科研項目2項，橫向課題3項，到位經(jīng)費400余萬元；發(fā)表SCI收錄論文80余篇，授權(quán)發(fā)明專利3件。基于原創(chuàng)噻吩[3,2-g]吲哚和噻吩[3,2-e]吲哚骨架設(shè)計合成了一系列新型具有近紅外吸收的苯并噻吩稠并BODIPY類光敏劑并進(jìn)行了活性評價，部分化合物具有顯著的光動力抗癌活性，該成果已實現(xiàn)轉(zhuǎn)化，合同金額30萬美元。2021和2022年連續(xù)兩次指導(dǎo)學(xué)生獲得全國大學(xué)生化學(xué)實驗創(chuàng)新設(shè)計大賽總決賽一等獎。

代表成果

[1] Xiaofan Fu, Yingxiu Man, Changjiang Yu*, Yingzhu Sun, Erhong Hao*, Qinghua Wu, Anzhi Hu, Guangyao Li, Chang-Cheng Wang*, and Jiazhu Li*, Unsymmetrical Benzothieno-Fused BODIPYs as Efficient NIR Heavy-Atom-Free Photosensitizers, J. Org. Chem., 2024, 89(7), 4826–4839.
[2] Xiangmin Wang, Xiaofan Fu, Weibin Bu, Changjiang Yu*, Erhong Hao, Lijuan Jiao, Qinghua Wu*, Rentian Wang, Jinjun Wang*, Jiazhu Li*, Bisbenzothieno[b]-fused BODIPYs as efficient near-infrared heavy-atom-free photosensitizers, Dyes Pigments, 2023, 219, 111591.
[3] Changjiang Yu*, Yingzhu Sun, Suowei Liu, Jiazhu Li*, Jinjun Wang, Yaxiong Wei, Xinsheng Xu*, Mengxue Yang, Lijuan Jiao, and Erhong Hao*, Twisted Benzothieno-Fused BOPHY Dyes as Triplet Photosensitizers with Long-Lived Triplet Excited States, Inorg. Chem., 2024, 63, 21898?21908.
[4] Weibin Bu, Changjiang Yu*, Yingxiu Man, Jiazhu Li*, Qinghua Wu, Shuangying Gui*, Yaxiong Wei*, Lijuan Jiao and Erhong Hao*, Heavy-atom-free triplet benzothiophene-fused BODIPY derivatives for lipid droplet-specific biomaging and photodynamic therapy, Chem. Commun., 2024, 60, 9809–9812.
[5] Chang-Cheng Wang*, Guangyao Li, Wenna Lv, Bin Yang, Jinchun Chen*, and Jiazhu Li*, Self-Photocatalyzed Oxidation of Alkylarenes to Carbonyls with Water, ACS Sustainable Chem. Eng., 2024, 12, 10647?10652.
[6] Changjiang Yu*, Yingzhu Sun, Qinghua Wu, Yongqiang Shi, Lijuan Jiao, Jinjun Wang, Xugang Guo, Jianfeng Li*, Jiazhu Li*, and Erhong Hao*, Synthesis, Properties, and Semiconducting Characteristics of Bisbenzothieno[b]?Fused BODIPYs, J. Org. Chem., 2023, 88, 14368-14376.
[7] Changjiang Yu*, Yingzhu Sun, Xingbao Fang, Jiazhu Li*, Qinghua Wu, Weibin Bu, Xing Guo, Hua Wang, Lijuan Jiao, and Erhong Hao*, Aromatic-Ring-Fused BOPPY Fluorophores: Synthesis, Spectral, Redox Properties, and Bioimaging Application, Inorg. Chem., 2022, 61, 16718-16729.
[8] Yuanyuan Zhao, Yu Zhao, Changjiang Yu*, Suowei Liu, Yang Liu, Erhong Hao*, Lijuan Jiao, Xinming Xu, Zhen Zhang*, Jiazhu Li*, A novel family of non-symmetric benzothieno[7,6-b]-fused BODIPYs: Synthesis, structures, photophysical properties and lipid droplet-specific imaging in vitro, Dyes Pigments, 2021, 196, 109748.
[9] Jiazhu Li*, Nailiang He, Yang Liu, Ziping Zhang, Xiao Zhang, Xueying Han, Yunyun Gai, Yongming Liu, Jungang Yin* and Jinjun Wang*, Synthesis and photophysical properties of novel pyridine fused chlorophyll a derivatives, Dyes Pigments, 2017, 146, 189-198.
[10] Jiazhu Li, Yang Liu, Xi-Sen Xu, Yan-Long Li, Shan-Guo Zhang, Il Yoon, Young Key Shim, Jin-Jun Wang* and Jun-Gang Yin*, Highly efficient synthesis of novel methyl 132-methylene mesopyropheophorbide a and its stereoselective Michael addition reaction, Org. Biomol. Chem., 2015, 13(7): 1992-1995.

*以上信息由高級會員個人更新和維護(hù)。