錢(qián)宇

男， 中山大學(xué)， 教授/研究員/教授級(jí)高工或同等級(jí)別

學(xué)習(xí)/工作經(jīng)歷

2003 - 2007，大連理工大學(xué)，制藥工程專(zhuān)業(yè)，學(xué)士, 導(dǎo)師：孟慶偉
2007 - 2013，華東師范大學(xué)，有機(jī)化學(xué)專(zhuān)業(yè)，博士，導(dǎo)師：胡文浩
2011 - 2013，美國(guó)馬里蘭大學(xué)，化學(xué)與生物化學(xué)系，聯(lián)合培養(yǎng)博士研究生&訪(fǎng)問(wèn)學(xué)者，導(dǎo)師：Michael P. Doyle
2013 - 2016，上海藥明康德新藥研發(fā)有限公司， 國(guó)際新藥研發(fā)部項(xiàng)目組長(zhǎng)
2016 - 2017，華東師范大學(xué)，化學(xué)與分子工程學(xué)院，副研究員
2017 - 2025，中山大學(xué)，藥學(xué)院，副教授
2025- 至今， 中山大學(xué)，藥學(xué)院，教授

研究領(lǐng)域和興趣

高效多組分合成新技術(shù)及在抗感染與抗腫瘤藥物開(kāi)發(fā)中的應(yīng)用

主要業(yè)績(jī)

中山大學(xué)“百人計(jì)劃”二期引進(jìn)人才，廣東省珠江人才創(chuàng)新團(tuán)隊(duì)核心成員，擔(dān)任廣東省化學(xué)會(huì)制藥工程專(zhuān)業(yè)委員會(huì)常務(wù)委員、廣東省藥理學(xué)會(huì)海洋藥物藥理專(zhuān)業(yè)委員會(huì)委員。主要從事功能型金屬卡賓類(lèi)中間體參與的多組分反應(yīng)研究，致力于發(fā)展高效、高選擇性的多官能團(tuán)化反應(yīng)新策略。開(kāi)創(chuàng)性提出“金屬卡拜等價(jià)物—葉立德—新金屬卡賓—葉立德—親電捕捉”的級(jí)聯(lián)轉(zhuǎn)化新路徑，突破了傳統(tǒng)有機(jī)合成依賴(lài)分步構(gòu)建碳碳鍵、碳雜原子鍵的固有模式。該路徑通過(guò)精準(zhǔn)調(diào)控金屬卡賓中間體的反應(yīng)活性，實(shí)現(xiàn)了多組分的高效協(xié)同轉(zhuǎn)化，建立了普適性的分子成鍵新方法，為復(fù)雜功能分子的精準(zhǔn)構(gòu)筑提供了原創(chuàng)性技術(shù)支撐。相關(guān)成果在藥物分子設(shè)計(jì)、功能材料開(kāi)發(fā)等領(lǐng)域展現(xiàn)出重要應(yīng)用前景。在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Nat. Commun.、Cancer Discov.、Chem. Sci.、Sci. China Chem.、J. Med. Chem.、Org. Lett. 等國(guó)際權(quán)威期刊發(fā)表SCI論文50余篇，獲授權(quán)發(fā)明專(zhuān)利10余項(xiàng)（含PCT專(zhuān)利2項(xiàng)）。主持（或參與）國(guó)家自然科學(xué)基金、國(guó)家重點(diǎn)研發(fā)計(jì)劃、科技部新藥創(chuàng)制重大專(zhuān)項(xiàng)子課題、廣東省自然科學(xué)基金、廣東省珠江人才創(chuàng)新團(tuán)隊(duì)項(xiàng)目、廣東省重點(diǎn)領(lǐng)域研發(fā)計(jì)劃重點(diǎn)項(xiàng)目等多項(xiàng)國(guó)家級(jí)及省部級(jí)科研項(xiàng)目。

代表成果

[1] Xiaoyan Yang, Xiaoyu Zhou, Wenhao Hu*, Yu Qian*, “Asymmetric multi-component trifunctionalization reactions with α-Halo Rh-carbenes”, Nat. Commun., 2025, DOI: 10.1038/s41467-025-56446-0.
[2] Taoda Shi,*, Yukai Li, Jiying Yang, Weining Weng, Mengchu Zhang, Jirong Shu, Yu Qian,* Tianyuan Zhang, Wenhao Hu*, “Multicatalysis-Enabled Multicomponent Reactions Generate a PTP1B Inhibitor” ACS Cent. Sci., 2025, DOI:10.1021/ acscentsci.5c00041.
[3] Mengchu Zhang, Xiaoyan Yang, Xiang Fu, Xiaoyu Zhou, Yu Qian*, Wenhao Hu*, “Chemo- and diastereoselective four-component reactions with Rh carbynoids”, Green Synthesis and Catalysis, 2024, DOI: 10.1016/j.gresc.2024.10.006
[4] Pei Li, Maoqing Shi, Kaixin Yang, Tongfei Jing, Zhenghui Kang,* Wenhao Hu, Yu Qian*, “Diastereoselective Synthesis of 4?Hydroxy-2-quinolinones via Formal [2 + 4] Cycloaddition Reactions Using α?Diazo Pyrazoleamides as C2 Synthons”, Org. Lett. 2024, DOI: 10.1021/acs.orglett.4c01956.
[5] Yu Qian*, Jie Tang, Xiaoyu Zhou, Jian Luo, Xiaoyan Yang, Zhuofeng Ke*, and Wenhao Hu*, “Enantioselective Multifunctionalization with Rh Carbynoids”, J. Am. Chem. Soc. 2023, DOI: 10.1021/jacs.3c10460
[6] Mengchu Zhang, Tianyuan Zhang, Sifan Yu, Huang Qiu, Abdulla Yusuf, Xinfang Xu, Yu Qian*, Wenhao Hu*, “Construction of 4-hydroxycoumarin derivatives with adjacent quaternary and tertiary stereocenters via ternary catalysis”, Chem. Sci., 2023, DOI: 10.1039/d3sc03452f.
[7] Aimin Xu, Xiaoyu Zhou, Rimei Zheng, Zhijing Zhang, Xinru Yin, Kemiao Hong, Zhuofeng Ke*, Yu Qian*, Wenhao Hu*, “Chiral rhodium(II)-catalyzed asymmetric aldol-type interception of an oxonium ylide to assemble chiral 2,3-dihydropyrans”, Sci. China Chem. 2022, DOI: 10.1007/s11426-022-1275-9.
[8] Liu Hu, Xing Cai, Suzhen Dong, Yongjia Zhen, Jidi Hu, Shenjun Wang, Jingwen Jiang, Jiawu Huang, Yuqiao Han, Yu Qian*, Yanqiu Yuan*, Wenhao Hu, “Synthesis and Anticancer Activity of Novel Actinonin Derivatives as HsPDF Inhibitors” J. Med. Chem. 2020, DOI: 10.1021/acs.jmedchem.0c00079.
[9] Xichen Xu#, Yu Qian#, Peter Y. Zavalij, Michael P. Doyle*, “Selective catalyst-dependent competitive 1,2-C→C, -O→C and -N→C migrations from β-methylene-β-silyloxy-β-amido-α-diazoacetates”, J. Am. Chem. Soc. 2013, DOI: 10.1021/ja311392m.
[10] Yu Qian, Xinfang Xu, Xiaochen Wang, Peter J. Zavalij, Wenhao Hu, Michael P. Doyle*, “Rhodium(II)- and Copper(II)-Catalyzed Reactions of Enol Diazoacetates with Nitrones: Metal Carbene versus Lewis Acid Directed Pathways”, Angew. Chem. Int. Ed. 2012, DOI: 10.1002/ange.201202525.

*以上信息由高級(jí)會(huì)員個(gè)人更新和維護(hù)。