分會

第四十六分會：納米材料的合成與組裝

摘要

Ag2S量子點修飾的自組裝二維肽納米片的仿生合成及應用 欒欣1，魏剛1,* 1青島大學化學與化工學院，青島市市南區(qū)寧夏路308號 266071； *Email: weigroup@qdu.edu.cn 光熱診療的基本原理是將光敏劑或納米材料靶向遞送至腫瘤細胞表面，然后利用近紅外光的組織穿透特性誘導光敏劑激發(fā)，將光能轉(zhuǎn)化為熱能，并進行近紅外成像，同時達到局部加熱細胞內(nèi)蛋白，破壞腫瘤細胞的目的1。近年來，基于近紅光照射的具有光熱特性的納米材料在生物醫(yī)學領(lǐng)域顯示出極好的潛力。迄今為止，已經(jīng)開發(fā)出一系列性能優(yōu)異的光熱納米材料，例如碳基材料、金屬硫化物和磁性納米粒子。其中，具有光熱療法特性的Ag2S量子點由于其優(yōu)異的近紅外熒光特性和生物相容性，在生物醫(yī)學應用中展現(xiàn)出巨大的潛力。然而，單一功能的光熱轉(zhuǎn)換材料已不能滿足當前腫瘤治療的需要，多功能、性質(zhì)可調(diào)的生物納米材料將具有更重要的研究意義2。由于肽對各種材料具有很高的親和力，多肽和其他材料形成的復合材料不僅具有多肽材料的高生物相容性，而且具有引入材料的獨特特性3。因此，利用多肽分子的高生物相容性、可降解性、自組裝性和仿生合成等優(yōu)勢，可以在一定程度上解決復合材料在腫瘤光熱和熒光成像中的難題。在這個項目中，我們通過多肽分子氨基酸序列的可控設計和功能調(diào)控合成了具有仿生能力的二維肽納米片。然后我們以硫醇封端的聚乙二醇作為穩(wěn)定劑在水相中制備了聚乙二醇化 Ag2S量子點。通過精確控制反應條件，我們獲得了發(fā)射峰在 1050 nm 左右的高發(fā)射聚乙二醇化 Ag2S 量子點，最后通過仿生合成方法制備了負載Ag2S的二維復合材料，用于體內(nèi)光熱治療和生物成像。該研究具有廣闊的生物醫(yī)學應用前景。 Fig. 1 Schematic diagram of the synthesis and application of peptide nanosheets loaded with PEGylated Ag2S QDs. 關(guān)鍵詞：多肽；硫化銀納米粒子；光熱治療；生物成像 致謝 感謝國家自然科學基金（No.51873225）、山東省泰山學者計劃（No.tsqn201909104）和青島大學高層次人才計劃的資助。 參考文獻 [1] Luan, X.; Kong, H.; He, P.; Yang, G. Z.; Zhu, D. Z. Small 2023, 19 (3). [2] Kong, H.; Han, J.; Yang, M. ; Lai, L. J. Mater. Chem. B 2023 [3] He, P.; Yang, G.; Zhu D. Kong,H. J. Nanobiotechnology 2022, 20: 483 Biomimetic synthesis and application of Ag2S QDs-modified self-assembled two-dimensional peptide nanosheets Xin Luan1, Gang Wei1, * 1 College of Chemistry and Chemical Engineering, Qingdao University, No. 308 Ningxia road, Shinan district, Qingdao 266071 *Email: weigroup@qdu.edu.cn The basic principle of photothermal therapy is to deliver photosensitizers or nanomaterials to the surface of tumor cells, and then use the tissue penetration properties of near-infrared (NIR) light to induce the excitation of photosensitizers, convert light energy into heat energy1. At the same time, it achieves the purpose of locally heating intracellular proteins and destroying tumor cells. In recent years, nanomaterials with photothermal properties based on NIR light irradiation have shown excellent potential in the field of biomedicine. So far, a series of photothermal nanomaterials with excellent properties have been developed, such as carbon-based material, metal sulfides, and magnetic nanoparticles. Among them, Ag2S QDs with photothermal properties have shown great potential in biomedical applications due to their excellent NIR fluorescence properties and biocompatibility. However, single-function photothermal conversion materials can no longer meet the needs of current tumor treatment, and bionanomaterials with multiple functions and adjustable properties will have more important research significance2. Due to the high affinity of peptides for various materials, the composite materials formed by peptides and other materials not only have the high biocompatibility of peptide materials but also have the unique characteristics of the introduced materials3. Therefore, using the advantages of peptide molecules can solve the problems of composite materials in tumor photothermal and fluorescence imaging to a certain extent. In this project, we synthesized two-dimensional peptide nanosheets with biomimetic capabilities through the controllable design and functional regulation of the amino acid sequence of peptide molecules. We then prepared PEGylated Ag2S QDs in an aqueous phase with thiol-terminated polyethylene glycol as a stabilizer. By precisely controlling the reaction conditions, we obtained high-emission PEGylated Ag2S QDs with emission peaks around 1050 nm, and finally prepared two-dimensional composites loaded with Ag2S for in vivo photothermal therapy and bioimaging. This study has broad prospects for biomedical applications.

關(guān)鍵詞

多肽;硫化銀量子點;光熱診療;生物成像;二維材料

線上墻報僅限年會已繳費參會代表觀看。

您還沒有登錄，請您先 點擊這里登錄

赫鵬 青島大學、欒欣 青島大學 共2人點贊了這篇線上墻報。